| Systems Biology - Properties of Reconstructed Networks |
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By: Palsson, Bernhard Ø. © 2006
Cambridge University Press
Description: This textbook describes how to model networks, how to determine their properties, and how to relate these to phenotypic functions. The prerequisites are some knowledge of linear algebra and biochemistry.
Front Matter
Text
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Preface
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Table of Contents
1. Introduction
2. Basic Concepts in Systems Biology
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Part I. Reconstruction of Biochemical Networks
3. Metabolic Networks
4. Transcriptional Regulatory Networks
5. Signaling Networks
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Part II. Mathematical Representation of Reconstructed Networks
6. Basic Features of the Stoichiometric Matrix
7. Topological Properties
8. Fundamental Subspaces of S
9. The (Right) Null Space of S
10. The Left Null Space of S
11. The Row and Column Spaces of S
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Part III. Capabilities of Reconstructed Networks
12. Dual Causality
13. Properties of Solution Spaces
14. Sampling Solution Spaces
15. Finding Functional States
16. Parametric Sensitivity
17. Epilogue
Appendices
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Bibliography
Index
